In the wake of the COVID-19 pandemic, laboratories faced unprecedented challenges, grappling with surging demand for diagnostic testing and operational bottlenecks. Our innovative approach harnesses agent-based modeling and Monte Carlo simulations to predict and quantify the impact of extreme disruptions on laboratory workflows. By simulating real-world scenarios, we uncover actionable strategies to enhance operational resilience and mitigate delays. Discover how our simulation-based framework not only forecasts longer turnaround times but also paves the way for agile responses in future crises, transforming laboratory operations and ensuring preparedness for large-scale challenges. Dive into the insights that could reshape the future of laboratory management.